Absorption of amino penicillins from everted rat intestine.
نویسندگان
چکیده
منابع مشابه
Autoradiographic Study of Sugar and Amino Acid Absorption by Everted Sacs of Hamster Intestine
Autoradiographs were prepared from frozen sections of everted sacs of hamster jejunum which had been incubated in vitro with C(14)- or H(3)-labeled sugars and amino acids. When such tissue was incubated in 1 mM solutions of L-valine or L-methionine, columnar absorptive cells at tips of villi accumulated these amino acids to concentrations ranging from 5 to 50 millimoles per liter of cells. Quan...
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Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...
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Etoposide, a widely used anticancer drug, exhibits low and variable oral bioavailability mainly because of being substrate for the efflux transporter, P-glycoprotein (P-gp). Therefore, the present study was aimed to investigate the effect of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and PEG 400 as P-gp inhibitors on the intestinal absorption of etoposide. Everted sacs of rat smal...
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Three decades have passed since Castle (1) and his associates demonstrated the existence of intrinsic factor, yet knowledge of its mechanism of action is still so limited that in 1958 two workers felt justified in concluding there was no such thing as intrinsic factor (2). In prior studies (3, 4), a mechanism involved in the enhanced uptake of vitamin B12 by rat liver slices in the presence of ...
متن کاملAromatic amino acid transaminase in rat intestine.
The transamination of aromatic l-amino acids (5-hydroxytryptophan, tryptophan, tyrosine, phenylalanine and kynurenine) was shown to be catalysed by enzyme preparations from rat small intestine. On the basis of the partial purification and characterization of these aromatic amino acid transaminases, it is suggested that rat small intestine contains several kinds of aromatic amino acid transamina...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1977
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1977.sp011914